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The nuclei ofsmooth muscle cells are located in the center of the cell andoftenhave a corkscrewappearancein longitudinal section. A detailed discussion of Tregs andimmune-based therapies will be presented in Chapter 4, but now it is important to understandthe concept of ?conversion? when examining the relationship between Tregs and the anti-tumor T cell response. In the firstcase, different types of responses will occur with acute,high-dose exposures as compared to those with chronic,low-dose exposures.
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